Molybdopterin synthase catalytic subunit (MOCS2)

About Molybdopterin synthase catalytic subunit

Molybdopterin synthase catalytic subunit (MOCS2) is a protein from Homo sapiens identified by UniProt accession O96007, 188 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

Target properties

Protein name	Molybdopterin synthase catalytic subunit
UniProt accession	O96007
Gene	MOCS2
Organism	Homo sapiens
Length	188 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (126)

Diseases linked to this target (Open Targets).

sulfite oxidase deficiency due to molybdenum cofactor deficiency type B · score 0.79
encephalopathy due to sulfite oxidase deficiency · score 0.55
sulfite oxidase deficiency due to molybdenum cofactor deficiency type A · score 0.46
intraocular pressure measurement · score 0.35
unipolar depression · score 0.31
attention deficit hyperactivity disorder · score 0.31
obsessive-compulsive disorder · score 0.31
autism spectrum disorder · score 0.31
Tourette syndrome · score 0.31
bipolar disorder · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O96007-F1	alphafold	PREDICTED	84.00	—

Amino-acid sequence (188 residues)

MSSLEISSSC FSLETKLPLS PPLVEDSAFE PSRKDMDEVE EKSKDVINFT AEKLSVDEVS QLVISPLCGA ISLFVGTTRN NFEGKKVISL EYEAYLPMAE NEVRKICSDI RQKWPVKHIA VFHRLGLVPV SEASIIIAVS SAHRAASLEA VSYAIDTLKA KVPIWKKEIY EESSTWKGNK ECFWASNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards