Napsin-A (NAPSA)

About Napsin-A

Napsin-A (NAPSA) is a protein from Homo sapiens identified by UniProt accession O96009, 420 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Napsin-A
UniProt accession	O96009
Gene	NAPSA
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.17
myoepithelial tumor · score 0.11
neoplasm · score 0.10
immature platelet fraction · score 0.07
adenocarcinoma · score 0.05
squamous cell carcinoma · score 0.04
non-small cell lung carcinoma · score 0.04
lung carcinoma · score 0.04
small cell carcinoma · score 0.04
COVID-19 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O96009-F1	alphafold	PREDICTED	82.45	—

Amino-acid sequence (420 residues)

MSPPPLLQPL LLLLPLLNVE PSGATLIRIP LHRVQPGRRI LNLLRGWREP AELPKLGAPS PGDKPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS NLWVPSRRCH FFSVPCWLHH RFDPKASSSF QANGTKFAIQ YGTGRVDGIL SEDKLTIGGI KGASVIFGEA LWEPSLVFAF AHFDGILGLG FPILSVEGVR PPMDVLVEQG LLDKPVFSFY LNRDPEEPDG GELVLGGSDP AHYIPPLTFV PVTVPAYWQI HMERVKVGPG LTLCAKGCAA ILDTGTSLIT GPTEEIRALH AAIGGIPLLA GEYIILCSEI PKLPAVSFLL GGVWFNLTAH DYVIQTTRNG VRLCLSGFQA LDVPPPAGPF WILGDVFLGT YVAVFDRGDM KSSARVGLAR ARTRGADLGW GETAQAQFPG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards