About Dynein axonemal light chain 4
Dynein axonemal light chain 4 (DNAL4) is a protein
from Homo sapiens identified by UniProt accession
O96015, 105 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Dynein axonemal light chain 4 |
|---|
| UniProt accession | O96015 |
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| Gene | DNAL4 |
|---|
| Organism | Homo sapiens |
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| Length | 105 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- mirror movements 3 · score 0.45
- familial congenital mirror movements · score 0.37
- neurodegenerative disease · score 0.27
- mathematical ability · score 0.14
- essential tremor · score 0.07
- Young adult-onset Parkinsonism · score 0.07
- Hereditary late-onset Parkinson disease · score 0.06
- Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
- X-linked dystonia-parkinsonism · score 0.06
- X-linked spinocerebellar ataxia type 4 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O96015-F1 | alphafold | PREDICTED | 90.43 | — |
Amino-acid sequence (105 residues)
MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC VWKCS
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