About Amyloid-beta A4 precursor protein-binding family A member 3
Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3) is a protein
from Homo sapiens identified by UniProt accession
O96018, 575 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Amyloid-beta A4 precursor protein-binding family A member 3 |
|---|
| UniProt accession | O96018 |
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| Gene | APBA3 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.39
- serum alanine aminotransferase measurement · score 0.38
- aspartate aminotransferase measurement · score 0.35
- sex hormone-binding globulin measurement · score 0.24
- neoplasm · score 0.10
- cancer · score 0.10
- pancreatic neoplasm · score 0.07
- triple-negative breast cancer · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.07
- infection · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O96018-F1 | alphafold | PREDICTED | 64.45 | — |
Amino-acid sequence (575 residues)
MDFPTISRSP SGPPAMDLEG PRDILVPSED LTPDSQWDPM PGGPGSLSRM ELDESSLQEL VQQFEALPGD LVGPSPGGAP CPLHIATGHG LASQEIADAH GLLSAEAGRD DLLGLLHCEE CPPSQTGPEE PLEPAPRLLQ PPEDPDEDSD SPEWVEGASA EQEGSRSSSS SPEPWLETVP LVTPEEPPAG AQSPETLASY PAPQEVPGPC DHEDLLDGVI FGARYLGSTQ LVSERNPPTS TRMAQAREAM DRVKAPDGET QPMTEVDLFV STKRIKVLTA DSQEAMMDHA LHTISYTADI GCVLVLMARR RLARRPAPQD HGRRLYKMLC HVFYAEDAQL IAQAIGQAFA AAYSQFLRES GIDPSQVGVH PSPGACHLHN GDLDHFSNSD NCREVHLEKR RGEGLGVALV ESGWGSLLPT AVIANLLHGG PAERSGALSI GDRLTAINGT SLVGLPLAAC QAAVRETKSQ TSVTLSIVHC PPVTTAIIHR PHAREQLGFC VEDGIICSLL RGGIAERGGI RVGHRIIEIN GQSVVATPHA RIIELLTEAY GEVHIKTMPA ATYRLLTGQE QPVYL
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