Actin-like protein 6A (ACTL6A)

About Actin-like protein 6A

Actin-like protein 6A (ACTL6A) is a protein from Homo sapiens identified by UniProt accession O96019, 429 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Actin-like protein 6A
UniProt accession	O96019
Gene	ACTL6A
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

Global developmental delay · score 0.41
neurodegenerative disease · score 0.40
Intellectual disability · score 0.37
complex neurodevelopmental disorder · score 0.37
Delayed speech and language development · score 0.31
Torticollis · score 0.27
atrial heart septal defect · score 0.27
gastroesophageal reflux disease · score 0.27
Inguinal hernia · score 0.27
Otitis media · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O96019-F1	alphafold	PREDICTED	91.57	—

Amino-acid sequence (429 residues)

MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLKN GMVEDWDSFQ AILDHTYKMH VKSEASLHPV LMSEAPWNTR AKREKLTELM FEHYNIPAFF LCKTAVLTAF ANGRSTGLIL DSGATHTTAI PVHDGYVLQQ GIVKSPLAGD FITMQCRELF QEMNIELVPP YMIASKEAVR EGSPANWKRK EKLPQVTRSW HNYMCNCVIQ DFQASVLQVS DSTYDEQVAA QMPTVHYEFP NGYNCDFGAE RLKIPEGLFD PSNVKGLSGN TMLGVSHVVT TSVGMCDIDI RPGLYGSVIV AGGNTLIQSF TDRLNRELSQ KTPPSMRLKL IANNTTVERR FSSWIGGSIL ASLGTFQQMW ISKQEYEEGG KQCVERKCP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards