G1/S-specific cyclin-E2 (CCNE2)

About G1/S-specific cyclin-E2

G1/S-specific cyclin-E2 (CCNE2) is a protein from Homo sapiens identified by UniProt accession O96020, 404 residues long. MolForge cross-references it against 0 known binders and 262 disease associations.

Target properties

Protein name	G1/S-specific cyclin-E2
UniProt accession	O96020
Gene	CCNE2
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (262)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
neurodevelopmental disorder with cerebellar hypoplasia and spasticity · score 0.33
glioblastoma multiforme · score 0.29
endometrial cancer · score 0.29
low grade glioma · score 0.29
head and neck squamous cell carcinoma · score 0.29
gastric adenocarcinoma · score 0.29
esophageal cancer · score 0.29
breast adenocarcinoma · score 0.29
squamous cell lung carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O96020-F1	alphafold	PREDICTED	77.52	—

Amino-acid sequence (404 residues)

MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWGCS KEVWLNMLKK ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP VTIISWLNLF LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP MEDRHNIQTH TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP PGKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards