Minor histocompatibility protein HB-1 (HMHB1)

About Minor histocompatibility protein HB-1

Minor histocompatibility protein HB-1 (HMHB1) is a protein from Homo sapiens identified by UniProt accession O97980, 41 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Minor histocompatibility protein HB-1
UniProt accession	O97980
Gene	HMHB1
Organism	Homo sapiens
Length	41 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

body height · score 0.39
heel bone mineral density · score 0.32
monocyte percentage of leukocytes · score 0.30
IGF-1 measurement · score 0.28
insulin like growth factor measurement · score 0.27
arterial stiffness measurement · score 0.13
response to bisphosphonate · score 0.10
atypical femoral fracture · score 0.10
acute lymphoblastic leukemia · score 0.03
drug use measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O97980-F1	alphafold	PREDICTED	72.41	—

Amino-acid sequence (41 residues)

MEEQPECREE KRGSLHVWKS ELVEVEDDVY LRHSSSLTYR L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards