All-trans-retinol dehydrogenase [NAD(+)] ADH1B (ADH1B)

About All-trans-retinol dehydrogenase [NAD(+)] ADH1B

All-trans-retinol dehydrogenase [NAD(+)] ADH1B (ADH1B) is a protein from Homo sapiens identified by UniProt accession P00325, 375 residues long. MolForge cross-references it against 0 known binders and 284 disease associations.

Target properties

Protein name	All-trans-retinol dehydrogenase [NAD(+)] ADH1B
UniProt accession	P00325
Gene	ADH1B
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (284)

Diseases linked to this target (Open Targets).

alcohol dependence · score 0.58
alcohol consumption measurement · score 0.49
alcohol use disorder measurement · score 0.49
alcohol dependence measurement · score 0.48
alcohol drinking · score 0.46
lipoprotein measurement · score 0.45
vitamin D measurement · score 0.44
longitudinal alcohol consumption measurement · score 0.44
low density lipoprotein cholesterol measurement · score 0.43
body mass index · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00325-F1	alphafold	PREDICTED	97.83	—

Amino-acid sequence (375 residues)

MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICHTD DHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV LPFEKINEGF DLLHSGKSIR TVLTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards