Alcohol dehydrogenase 1C (ADH1C)

About Alcohol dehydrogenase 1C

Alcohol dehydrogenase 1C (ADH1C) is a protein from Homo sapiens identified by UniProt accession P00326, 375 residues long. MolForge cross-references it against 0 known binders and 188 disease associations.

Target properties

Protein name	Alcohol dehydrogenase 1C
UniProt accession	P00326
Gene	ADH1C
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (188)

Diseases linked to this target (Open Targets).

alcohol dependence · score 0.56
alcohol consumption measurement · score 0.54
IGF-1 measurement · score 0.51
alcohol drinking · score 0.48
alcohol use disorder measurement · score 0.45
hemoglobin measurement · score 0.43
alcohol dependence measurement · score 0.43
apolipoprotein A 1 measurement · score 0.42
alkaline phosphatase measurement · score 0.41
high density lipoprotein cholesterol measurement · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00326-F1	alphafold	PREDICTED	98.11	—

Amino-acid sequence (375 residues)

MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD EHVVSGNLVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRICKNPESN YCLKNDLGNP RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI LPFEKINEGF DLLRSGKSIR TVLTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards