NADH-cytochrome b5 reductase 3 (CYB5R3)

About NADH-cytochrome b5 reductase 3

NADH-cytochrome b5 reductase 3 (CYB5R3) is a protein from Homo sapiens identified by UniProt accession P00387, 301 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	NADH-cytochrome b5 reductase 3
UniProt accession	P00387
Gene	CYB5R3
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

Recessive hereditary methemoglobinemia type 2 · score 0.81
Recessive hereditary methemoglobinemia type 1 · score 0.81
methemoglobinemia · score 0.65
hereditary methemoglobinemia · score 0.64
Autosomal dominant methemoglobinemia · score 0.52
Caffey disease · score 0.33
p phenotype · score 0.28
mean corpuscular volume · score 0.27
Red cell distribution width · score 0.26
hemoglobin measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00387-F1	alphafold	PREDICTED	93.85	—

Amino-acid sequence (301 residues)

MGAQLSTLGH MVLFPVWFLY SLLMKLFQRS TPAITLESPD IKYPLRLIDR EIISHDTRRF RFALPSPQHI LGLPVGQHIY LSARIDGNLV VRPYTPISSD DDKGFVDLVI KVYFKDTHPK FPAGGKMSQY LESMQIGDTI EFRGPSGLLV YQGKGKFAIR PDKKSNPIIR TVKSVGMIAG GTGITPMLQV IRAIMKDPDD HTVCHLLFAN QTEKDILLRP ELEELRNKHS ARFKLWYTLD RAPEAWDYGQ GFVNEEMIRD HLPPPEEEPL VLMCGPPPMI QYACLPNLDH VGHPTERCFV F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards