About Cytochrome c oxidase subunit 1
Cytochrome c oxidase subunit 1 (MT-CO1) is a protein
from Homo sapiens identified by UniProt accession
P00395, 513 residues long.
MolForge cross-references it against 0 known binders and
343 disease associations.
Target properties
| Protein name | Cytochrome c oxidase subunit 1 |
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| UniProt accession | P00395 |
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| Gene | MT-CO1 |
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| Organism | Homo sapiens |
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| Length | 513 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (343)
Diseases linked to this target (Open Targets).
- mitochondrial disease · score 0.70
- Leber hereditary optic neuropathy · score 0.68
- Mitochondrial non-syndromic sensorineural deafness · score 0.68
- MELAS · score 0.66
- mitochondrial non-syndromic sensorineural hearing loss · score 0.66
- refractory anemia with ringed sideroblasts · score 0.63
- myoglobinuria, recurrent · score 0.63
- Isolated cytochrome C oxidase deficiency · score 0.60
- MELAS syndrome · score 0.57
- Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00395-F1 | alphafold | PREDICTED | 95.77 | — |
Amino-acid sequence (513 residues)
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS
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