About Phenylalanine-4-hydroxylase
Phenylalanine-4-hydroxylase (PAH) is a protein
from Homo sapiens identified by UniProt accession
P00439, 452 residues long.
MolForge cross-references it against 0 known binders and
241 disease associations.
Target properties
| Protein name | Phenylalanine-4-hydroxylase |
|---|
| UniProt accession | P00439 |
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| Gene | PAH |
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| Organism | Homo sapiens |
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| Length | 452 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (241)
Diseases linked to this target (Open Targets).
- phenylketonuria · score 0.90
- Maternal hyperphenylalaninemia · score 0.82
- phenylalanine measurement · score 0.70
- Hyperphenylalaninemia · score 0.67
- genetic disorder · score 0.55
- 6-pyruvoyl-tetrahydropterin synthase deficiency · score 0.51
- BH4-deficient hyperphenylalaninemia A · score 0.51
- amino acid measurement · score 0.48
- pulmonary hypertension, primary, 1 · score 0.46
- peripheral arterial disease · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00439-F1 | alphafold | PREDICTED | 88.68 | — |
Amino-acid sequence (452 residues)
MSTAVLENPG LGRKLSDFGQ ETSYIEDNCN QNGAISLIFS LKEEVGALAK VLRLFEENDV NLTHIESRPS RLKKDEYEFF THLDKRSLPA LTNIIKILRH DIGATVHELS RDKKKDTVPW FPRTIQELDR FANQILSYGA ELDADHPGFK DPVYRARRKQ FADIAYNYRH GQPIPRVEYM EEEKKTWGTV FKTLKSLYKT HACYEYNHIF PLLEKYCGFH EDNIPQLEDV SQFLQTCTGF RLRPVAGLLS SRDFLGGLAF RVFHCTQYIR HGSKPMYTPE PDICHELLGH VPLFSDRSFA QFSQEIGLAS LGAPDEYIEK LATIYWFTVE FGLCKQGDSI KAYGAGLLSS FGELQYCLSE KPKLLPLELE KTAIQNYTVT EFQPLYYVAE SFNDAKEKVR NFAATIPRPF SVRYDPYTQR IEVLDNTQQL KILADSINSE IGILCSALQK IK
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