About Coagulation factor XIII A chain
Coagulation factor XIII A chain (F13A1) is a protein
from Homo sapiens identified by UniProt accession
P00488, 732 residues long.
MolForge cross-references it against 0 known binders and
320 disease associations.
Target properties
| Protein name | Coagulation factor XIII A chain |
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| UniProt accession | P00488 |
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| Gene | F13A1 |
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| Organism | Homo sapiens |
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| Length | 732 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (320)
Diseases linked to this target (Open Targets).
- factor XIII, A subunit, deficiency of · score 0.82
- Factor XIII subunit A deficiency · score 0.56
- congenital factor XIII deficiency · score 0.50
- blood protein measurement · score 0.49
- coagulation factor measurement · score 0.47
- PHF-tau measurement · score 0.41
- neurodegenerative disease · score 0.39
- hemorrhage · score 0.37
- Rare genetic coagulation disorder · score 0.37
- glucose tolerance test · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00488-F1 | alphafold | PREDICTED | 90.90 | — |
Amino-acid sequence (732 residues)
MSETSRTAFG GRRAVPPNNS NAAEDDLPTV ELQGVVPRGV NLQEFLNVTS VHLFKERWDT NKVDHHTDKY ENNKLIVRRG QSFYVQIDFS RPYDPRRDLF RVEYVIGRYP QENKGTYIPV PIVSELQSGK WGAKIVMRED RSVRLSIQSS PKCIVGKFRM YVAVWTPYGV LRTSRNPETD TYILFNPWCE DDAVYLDNEK EREEYVLNDI GVIFYGEVND IKTRSWSYGQ FEDGILDTCL YVMDRAQMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNIYAYGVPP SAWTGSVDIL LEYRSSENPV RYGQCWVFAG VFNTFLRCLG IPARIVTNYF SAHDNDANLQ MDIFLEEDGN VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAIKH GHVCFQFDAP FVFAEVNSDL IYITAKKDGT HVVENVDATH IGKLIVTKQI GGDGMMDITD TYKFQEGQEE ERLALETALM YGAKKPLNTE GVMKSRSNVD MDFEVENAVL GKDFKLSITF RNNSHNRYTI TAYLSANITF YTGVPKAEFK KETFDVTLEP LSFKKEAVLI QAGEYMGQLL EQASLHFFVT ARINETRDVL AKQKSTVLTI PEIIIKVRGT QVVGSDMTVT VEFTNPLKET LRNVWVHLDG PGVTRPMKKM FREIRPNSTV QWEEVCRPWV SGHRKLIASM SSDSLRHVYG ELDVQIQRRP SM
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