Purine nucleoside phosphorylase (PNP)

About Purine nucleoside phosphorylase

Purine nucleoside phosphorylase (PNP) is a protein from Homo sapiens identified by UniProt accession P00491, 289 residues long. MolForge cross-references it against 0 known binders and 271 disease associations.

Target properties

Protein name	Purine nucleoside phosphorylase
UniProt accession	P00491
Gene	PNP
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (271)

Diseases linked to this target (Open Targets).

purine nucleoside phosphorylase deficiency · score 0.80
Combined immunodeficiency · score 0.46
combined immunodeficiency · score 0.46
T-B+ severe combined immunodeficiency · score 0.46
severe combined immunodeficiency · score 0.46
aspartate aminotransferase measurement · score 0.37
serum alanine aminotransferase measurement · score 0.36
blood protein measurement · score 0.34
age at menopause · score 0.34
mitochondrial DNA measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00491-F1	alphafold	PREDICTED	93.81	—

Amino-acid sequence (289 residues)

MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards