About Aspartate aminotransferase, mitochondrial
Aspartate aminotransferase, mitochondrial (GOT2) is a protein
from Homo sapiens identified by UniProt accession
P00505, 430 residues long.
MolForge cross-references it against 0 known binders and
295 disease associations.
Target properties
| Protein name | Aspartate aminotransferase, mitochondrial |
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| UniProt accession | P00505 |
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| Gene | GOT2 |
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| Organism | Homo sapiens |
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| Length | 430 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (295)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.61
- aspartate aminotransferase measurement · score 0.47
- neurodegenerative disease · score 0.35
- serum metabolite measurement · score 0.34
- blood metabolite measurement · score 0.33
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.29
- self reported educational attainment · score 0.27
- urinary metabolite measurement · score 0.24
- neuroimaging measurement · score 0.22
- liver fibrosis measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00505-F1 | alphafold | PREDICTED | 94.27 | — |
Amino-acid sequence (430 residues)
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEV LKSGRFVTVQ TISGTGALRI GASFLQRFFK FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR YYDPKTCGFD FTGAVEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR IIGMRTQLVS NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI YMTKDGRISV AGVTSSNVGY LAHAIHQVTK
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