About Proto-oncogene serine/threonine-protein kinase mos
Proto-oncogene serine/threonine-protein kinase mos (MOS) is a protein
from Homo sapiens identified by UniProt accession
P00540, 346 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Proto-oncogene serine/threonine-protein kinase mos |
|---|
| UniProt accession | P00540 |
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| Gene | MOS |
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| Organism | Homo sapiens |
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| Length | 346 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (115)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- body height · score 0.24
- refractive error measurement · score 0.12
- reticulocyte count · score 0.11
- reticulocyte measurement · score 0.10
- appendicular lean mass · score 0.09
- monocyte count · score 0.08
- platelet crit · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- primary ovarian insufficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00540-F1 | alphafold | PREDICTED | 80.36 | — |
Amino-acid sequence (346 residues)
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
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