About Phosphoglycerate kinase 1
Phosphoglycerate kinase 1 (PGK1) is a protein
from Homo sapiens identified by UniProt accession
P00558, 417 residues long.
MolForge cross-references it against 0 known binders and
245 disease associations.
Target properties
| Protein name | Phosphoglycerate kinase 1 |
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| UniProt accession | P00558 |
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| Gene | PGK1 |
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| Organism | Homo sapiens |
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| Length | 417 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (245)
Diseases linked to this target (Open Targets).
- glycogen storage disease due to phosphoglycerate kinase 1 deficiency · score 0.82
- Menkes disease · score 0.58
- X-linked distal spinal muscular atrophy type 3 · score 0.56
- occipital horn syndrome · score 0.56
- neurodegenerative disease · score 0.51
- genetic disorder · score 0.51
- tuberculosis · score 0.37
- azoospermia · score 0.26
- Ehlers-Danlos syndrome · score 0.18
- Charcot-Marie-Tooth disease · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00558-F1 | alphafold | PREDICTED | 96.38 | — |
Amino-acid sequence (417 residues)
MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV GPEVEKACAN PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSNI
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