About Adenylate kinase isoenzyme 1
Adenylate kinase isoenzyme 1 (AK1) is a protein
from Homo sapiens identified by UniProt accession
P00568, 194 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Adenylate kinase isoenzyme 1 |
|---|
| UniProt accession | P00568 |
|---|
| Gene | AK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 194 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- hemolytic anemia due to adenylate kinase deficiency · score 0.75
- hemoglobin measurement · score 0.32
- hematocrit · score 0.31
- red blood cell density measurement · score 0.25
- mean platelet volume · score 0.22
- urate measurement · score 0.20
- erythrocyte count · score 0.19
- bilirubin measurement · score 0.15
- mean corpuscular hemoglobin concentration · score 0.12
- P-selectin glycoprotein ligand 1 measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00568-F1 | alphafold | PREDICTED | 95.87 | — |
Amino-acid sequence (194 residues)
MEEKLKKTKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRSEVSSG SARGKKLSEI MEKGQLVPLE TVLDMLRDAM VAKVNTSKGF LIDGYPREVQ QGEEFERRIG QPTLLLYVDA GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD SVFSQVCTHL DALK
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