Haptoglobin (HP)

About Haptoglobin

Haptoglobin (HP) is a protein from Homo sapiens identified by UniProt accession P00738, 406 residues long. MolForge cross-references it against 0 known binders and 1,045 disease associations.

Target properties

Protein name	Haptoglobin
UniProt accession	P00738
Gene	HP
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1045)

Diseases linked to this target (Open Targets).

anhaptoglobinemia · score 0.43
haptoglobin measurement · score 0.27
blood protein measurement · score 0.26
low density lipoprotein cholesterol measurement · score 0.22
serum alanine aminotransferase measurement · score 0.22
total cholesterol measurement · score 0.22
smoking status measurement · score 0.21
unipolar depression · score 0.20
erythrocyte count · score 0.19
bipolar disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00738-F1	alphafold	PREDICTED	84.80	—

Amino-acid sequence (406 residues)

MSALGAVIAL LLWGQLFAVD SGNDVTDIAD DGCPKPPEIA HGYVEHSVRY QCKNYYKLRT EGDGVYTLND KKQWINKAVG DKLPECEADD GCPKPPEIAH GYVEHSVRYQ CKNYYKLRTE GDGVYTLNNE KQWINKAVGD KLPECEAVCG KPKNPANPVQ RILGGHLDAK GSFPWQAKMV SHHNLTTGAT LINEQWLLTT AKNLFLNHSE NATAKDIAPT LTLYVGKKQL VEIEKVVLHP NYSQVDIGLI KLKQKVSVNE RVMPICLPSK DYAEVGRVGY VSGWGRNANF KFTDHLKYVM LPVADQDQCI RHYEGSTVPE KKTPKSPVGV QPILNEHTFC AGMSKYQEDT CYGDAGSAFA VHDLEEDTWY ATGILSFDKS CAVAEYGVYV KVTSIQDWVQ KTIAEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards