Haptoglobin-related protein (HPR)

About Haptoglobin-related protein

Haptoglobin-related protein (HPR) is a protein from Homo sapiens identified by UniProt accession P00739, 348 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.

Target properties

Protein name	Haptoglobin-related protein
UniProt accession	P00739
Gene	HPR
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (209)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.49
total cholesterol measurement · score 0.47
apolipoprotein B measurement · score 0.42
haptoglobin measurement · score 0.41
serum albumin measurement · score 0.37
triglyceride measurement · score 0.37
Hypercholesterolemia · score 0.36
blood protein measurement · score 0.33
bilirubin measurement · score 0.30
alcohol consumption measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00739-F1	alphafold	PREDICTED	87.66	—

Amino-acid sequence (348 residues)

MSDLGAVISL LLWGRQLFAL YSGNDVTDIS DDRFPKPPEI ANGYVEHLFR YQCKNYYRLR TEGDGVYTLN DKKQWINKAV GDKLPECEAV CGKPKNPANP VQRILGGHLD AKGSFPWQAK MVSHHNLTTG ATLINEQWLL TTAKNLFLNH SENATAKDIA PTLTLYVGKK QLVEIEKVVL HPNYHQVDIG LIKLKQKVLV NERVMPICLP SKNYAEVGRV GYVSGWGQSD NFKLTDHLKY VMLPVADQYD CITHYEGSTC PKWKAPKSPV GVQPILNEHT FCVGMSKYQE DTCYGDAGSA FAVHDLEEDT WYAAGILSFD KSCAVAEYGV YVKVTSIQHW VQKTIAEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards