Coagulation factor IX (F9)

About Coagulation factor IX

Coagulation factor IX (F9) is a protein from Homo sapiens identified by UniProt accession P00740, 461 residues long. MolForge cross-references it against 0 known binders and 280 disease associations.

Target properties

Protein name	Coagulation factor IX
UniProt accession	P00740
Gene	F9
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (280)

Diseases linked to this target (Open Targets).

hemophilia B · score 0.89
hemophilia A · score 0.76
thrombophilia, X-linked, due to factor 9 defect · score 0.73
Venous thrombosis · score 0.68
x-linked warfarin sensitivity · score 0.61
hemophilia b leyden · score 0.50
hemorrhage · score 0.46
severe hemophilia B · score 0.45
Abnormality of coagulation · score 0.44
severe hemophilia A · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00740-F1	alphafold	PREDICTED	80.29	—

Amino-acid sequence (461 residues)

MQRVNMIMAE SPGLITICLL GYLLSAECTV FLDHENANKI LNRPKRYNSG KLEEFVQGNL ERECMEEKCS FEEAREVFEN TERTTEFWKQ YVDGDQCESN PCLNGGSCKD DINSYECWCP FGFEGKNCEL DVTCNIKNGR CEQFCKNSAD NKVVCSCTEG YRLAENQKSC EPAVPFPCGR VSVSQTSKLT RAETVFPDVD YVNSTEAETI LDNITQSTQS FNDFTRVVGG EDAKPGQFPW QVVLNGKVDA FCGGSIVNEK WIVTAAHCVE TGVKITVVAG EHNIEETEHT EQKRNVIRII PHHNYNAAIN KYNHDIALLE LDEPLVLNSY VTPICIADKE YTNIFLKFGS GYVSGWGRVF HKGRSALVLQ YLRVPLVDRA TCLRSTKFTI YNNMFCAGFH EGGRDSCQGD SGGPHVTEVE GTSFLTGIIS WGEECAMKGK YGIYTKVSRY VNWIKEKTKL T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards