Complement factor D (CFD)

About Complement factor D

Complement factor D (CFD) is a protein from Homo sapiens identified by UniProt accession P00746, 253 residues long. MolForge cross-references it against 0 known binders and 287 disease associations.

Target properties

Protein name	Complement factor D
UniProt accession	P00746
Gene	CFD
Organism	Homo sapiens
Length	253 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (287)

Diseases linked to this target (Open Targets).

recurrent Neisseria infections due to factor D deficiency · score 0.73
atrophic macular degeneration · score 0.36
paroxysmal nocturnal hemoglobinuria · score 0.34
reticulocyte count · score 0.33
neurodegenerative disease · score 0.32
monocyte percentage of leukocytes · score 0.28
Immature Reticulocyte Fraction Measurement · score 0.21
complement component C8 measurement · score 0.18
reticulocyte measurement · score 0.15
neurofibrillary tangles measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00746-F1	alphafold	PREDICTED	90.99	—

Amino-acid sequence (253 residues)

MHSWERLAVL VLLGAAACAA PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR VASYAAWIDS VLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards