About Complement factor B
Complement factor B (CFB) is a protein
from Homo sapiens identified by UniProt accession
P00751, 764 residues long.
MolForge cross-references it against 0 known binders and
454 disease associations.
Target properties
| Protein name | Complement factor B |
|---|
| UniProt accession | P00751 |
|---|
| Gene | CFB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 764 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (454)
Diseases linked to this target (Open Targets).
- atypical hemolytic-uremic syndrome with B factor anomaly · score 0.77
- atypical hemolytic-uremic syndrome · score 0.63
- Immunodeficiency due to a complement cascade protein anomaly · score 0.61
- age-related macular degeneration · score 0.58
- lymphocyte count · score 0.49
- primary membranoproliferative glomerulonephritis · score 0.44
- non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.44
- leukocyte count · score 0.43
- blood protein measurement · score 0.41
- paroxysmal nocturnal hemoglobinuria · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00751-F1 | alphafold | PREDICTED | 86.25 | — |
Amino-acid sequence (764 residues)
MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFYQMID ESQSLSLCGM VWEHRKGTDY HKQPWQAKIS VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS VGGEKRDLEI EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKEKLQDED LGFL
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