Adenosine deaminase (ADA)

About Adenosine deaminase

Adenosine deaminase (ADA) is a protein from Homo sapiens identified by UniProt accession P00813, 363 residues long. MolForge cross-references it against 0 known binders and 921 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (921)

Diseases linked to this target (Open Targets).

• severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency · score 0.85
• Severe combined immunodeficiency due to adenosine deaminase deficiency · score 0.85
• severe combined immunodeficiency · score 0.64
• partial adenosine deaminase deficiency · score 0.51
• chronic lymphocytic leukemia · score 0.47
• Omenn syndrome · score 0.46
• serum metabolite measurement · score 0.45
• neoplasm · score 0.40
• hairy cell leukemia · score 0.39
• immune system disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (363 residues)

External references