Argininosuccinate synthase (ASS1)

About Argininosuccinate synthase

Argininosuccinate synthase (ASS1) is a protein from Homo sapiens identified by UniProt accession P00966, 412 residues long. MolForge cross-references it against 0 known binders and 341 disease associations.

Target properties

Protein name	Argininosuccinate synthase
UniProt accession	P00966
Gene	ASS1
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (341)

Diseases linked to this target (Open Targets).

citrullinemia type I · score 0.85
citrullinemia · score 0.71
genetic disorder · score 0.47
Intellectual disability · score 0.37
acute neonatal citrullinemia type I · score 0.37
adult-onset citrullinemia type I · score 0.37
citrullinemia type II · score 0.34
bone density · score 0.34
urate measurement · score 0.34
lung carcinoma · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00966-F1	alphafold	PREDICTED	95.52	—

Amino-acid sequence (412 residues)

MSSKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF IEDVSREFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG KGNDQVRFEL SCYSLAPQIK VIAPWRMPEF YNRFKGRNDL MEYAKQHGIP IPVTPKNPWS MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNTP DILEIEFKKG VPVKVTNVKD GTTHQTSLEL FMYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ VSVLKGQVYI LGRESPLSLY NEELVSMNVQ GDYEPTDATG FININSLRLK EYHRLQSKVT AK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards