2'-5'-oligoadenylate synthase 1 (OAS1)

About 2'-5'-oligoadenylate synthase 1

2'-5'-oligoadenylate synthase 1 (OAS1) is a protein from Homo sapiens identified by UniProt accession P00973, 400 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.

Target properties

Protein name	2'-5'-oligoadenylate synthase 1
UniProt accession	P00973
Gene	OAS1
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (233)

Diseases linked to this target (Open Targets).

pulmonary alveolar proteinosis with hypogammaglobulinemia · score 0.60
COVID-19 · score 0.37
neurodegenerative disease · score 0.32
urate measurement · score 0.26
systemic lupus erythematosus · score 0.22
serum gamma-glutamyl transferase measurement · score 0.22
hypertension · score 0.20
type 2 diabetes mellitus · score 0.20
chronic lymphocytic leukemia · score 0.19
thyroid gland adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00973-F1	alphafold	PREDICTED	83.91	—

Amino-acid sequence (400 residues)

MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN SADDETDDPR RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards