Antithrombin-III (SERPINC1)

About Antithrombin-III

Antithrombin-III (SERPINC1) is a protein from Homo sapiens identified by UniProt accession P01008, 464 residues long. MolForge cross-references it against 0 known binders and 652 disease associations.

Target properties

Protein name	Antithrombin-III
UniProt accession	P01008
Gene	SERPINC1
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (652)

Diseases linked to this target (Open Targets).

hereditary antithrombin deficiency · score 0.85
Venous thrombosis · score 0.71
venous thromboembolism · score 0.66
deep vein thrombosis · score 0.65
pulmonary embolism · score 0.60
atrial fibrillation · score 0.60
myocardial infarction · score 0.60
Reduced antithrombin III activity · score 0.59
COVID-19 · score 0.58
Thromboembolism · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01008-F1	alphafold	PREDICTED	84.68	—

Amino-acid sequence (464 residues)

MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAKPRDIPMN PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNETY QDISELVYGA KLQPLDFKEN AEQSRAAINK WVSNKTEGRI TDVIPSEAIN ELTVLVLVNT IYFKGLWKSK FSPENTRKEL FYKADGESCS ASMMYQEGKF RYRRVAEGTQ VLELPFKGDD ITMVLILPKP EKSLAKVEKE LTPEVLQEWL DELEEMMLVV HMPRFRIEDG FSLKEQLQDM GLVDLFSPEK SKLPGIVAEG RDDLYVSDAF HKAFLEVNEE GSEAAASTAV VIAGRSLNPN RVTFKANRPF LVFIREVPLN TIIFMGRVAN PCVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards