Alpha-1-antitrypsin (SERPINA1)

About Alpha-1-antitrypsin

Alpha-1-antitrypsin (SERPINA1) is a protein from Homo sapiens identified by UniProt accession P01009, 418 residues long. MolForge cross-references it against 0 known binders and 1,102 disease associations.

Target properties

Protein name	Alpha-1-antitrypsin
UniProt accession	P01009
Gene	SERPINA1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1102)

Diseases linked to this target (Open Targets).

Alpha-1-antitrypsin deficiency · score 0.71
alpha 1-antitrypsin deficiency · score 0.60
chronic obstructive pulmonary disease · score 0.59
blood protein measurement · score 0.50
serum albumin measurement · score 0.50
sex hormone-binding globulin measurement · score 0.50
genetic disorder · score 0.49
platelet count · score 0.48
testosterone measurement · score 0.48
refractive error measurement · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01009-F1	alphafold	PREDICTED	88.60	—

Amino-acid sequence (418 residues)

MPSSVSWGIL LLAGLCCLVP VSLAEDPQGD AAQKTDTSHH DQDHPTFNKI TPNLAEFAFS LYRQLAHQSN STNIFFSPVS IATAFAMLSL GTKADTHDEI LEGLNFNLTE IPEAQIHEGF QELLRTLNQP DSQLQLTTGN GLFLSEGLKL VDKFLEDVKK LYHSEAFTVN FGDTEEAKKQ INDYVEKGTQ GKIVDLVKEL DRDTVFALVN YIFFKGKWER PFEVKDTEEE DFHVDQVTTV KVPMMKRLGM FNIQHCKKLS SWVLLMKYLG NATAIFFLPD EGKLQHLENE LTHDIITKFL ENEDRRSASL HLPKLSITGT YDLKSVLGQL GITKVFSNGA DLSGVTEEAP LKLSKAVHKA VLTIDEKGTE AAGAMFLEAI PMSIPPEVKF NKPFVFLMIE QNTKSPLFMG KVVNPTQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards