Alpha-1-antichymotrypsin (SERPINA3)

About Alpha-1-antichymotrypsin

Alpha-1-antichymotrypsin (SERPINA3) is a protein from Homo sapiens identified by UniProt accession P01011, 423 residues long. MolForge cross-references it against 0 known binders and 422 disease associations.

Target properties

Protein name	Alpha-1-antichymotrypsin
UniProt accession	P01011
Gene	SERPINA3
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (422)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.37
cathepsin L1 measurement · score 0.26
alpha-1-antichymotrypsin complex measurement · score 0.25
alpha-1-antichymotrypsin measurement · score 0.25
breast adenocarcinoma · score 0.25
glioblastoma multiforme · score 0.16
sex hormone-binding globulin measurement · score 0.15
total blood protein measurement · score 0.13
peripheral arterial occlusive disease 1 · score 0.12
serum albumin measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01011-F1	alphafold	PREDICTED	85.21	—

Amino-acid sequence (423 residues)

MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP KQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards