Angiotensinogen (AGT)

About Angiotensinogen

Angiotensinogen (AGT) is a protein from Homo sapiens identified by UniProt accession P01019, 476 residues long. MolForge cross-references it against 0 known binders and 1,137 disease associations.

Target properties

Protein name	Angiotensinogen
UniProt accession	P01019
Gene	AGT
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1137)

Diseases linked to this target (Open Targets).

renal tubular dysgenesis · score 0.68
renal tubular dysgenesis of genetic origin · score 0.64
hypertension · score 0.62
essential hypertension, genetic · score 0.60
systolic blood pressure · score 0.47
diastolic blood pressure · score 0.46
blood protein measurement · score 0.40
cardiovascular disease · score 0.39
congenital anomaly of kidney and urinary tract · score 0.37
mean arterial pressure · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01019-F1	alphafold	PREDICTED	86.45	—

Amino-acid sequence (476 residues)

MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA GKPKDPTFIP APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML ANFLGFRIYG MHSELWGVVH GATVLSPTAV FGTLASLYLG ALDHTADRLQ AILGVPWKDK NCTSRLDAHK VLSALQAVQG LLVAQGRADS QAQLLLSTVV GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE KIDRFMQAVT GWKTGCSLMG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS VPMLSGMGTF QHWSDIQDNF SVTQVPFTES ACLLLIQPHY ASDLDKVEGL TFQQNSLNWM KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL NLQKLSNDRI RVGEVLNSIF FELEADEREP TESTQQLNKP EVLEVTLNRP FLFAVYDQSA TALHFLGRVA NPLSTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards