About Cystatin-C
Cystatin-C (CST3) is a protein
from Homo sapiens identified by UniProt accession
P01034, 146 residues long.
MolForge cross-references it against 0 known binders and
799 disease associations.
Target properties
| Protein name | Cystatin-C |
|---|
| UniProt accession | P01034 |
|---|
| Gene | CST3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 146 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (799)
Diseases linked to this target (Open Targets).
- cystatin C measurement · score 0.70
- ACys amyloidosis · score 0.48
- Hereditary cerebral hemorrhage with amyloidosis · score 0.48
- age related macular degeneration 11 · score 0.47
- age-related macular degeneration · score 0.47
- AL amyloidosis · score 0.46
- blood protein measurement · score 0.39
- Hereditary cerebral hemorrhage with amyloidosis, Icelandic type · score 0.37
- chronic kidney disease · score 0.33
- protein measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01034-F1 | alphafold | PREDICTED | 88.66 | — |
Amino-acid sequence (146 residues)
MAGPLRAPLL LLAILAVALA VSPAAGSSPG KPPRLVGGPM DASVEEEGVR RALDFAVGEY NKASNDMYHS RALQVVRARK QIVAGVNYFL DVELGRTTCT KTQPNLDNCP FHDQPHLKRK AFCSFQIYAV PWQGTMTLSK STCQDA
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