Cystatin-S (CST4)

About Cystatin-S

Cystatin-S (CST4) is a protein from Homo sapiens identified by UniProt accession P01036, 141 residues long. MolForge cross-references it against 0 known binders and 270 disease associations.

Target properties

Protein name	Cystatin-S
UniProt accession	P01036
Gene	CST4
Organism	Homo sapiens
Length	141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (270)

Diseases linked to this target (Open Targets).

cystatin C measurement · score 0.43
glomerular filtration rate · score 0.24
cerebrospinal fluid biomarker measurement · score 0.21
blood protein measurement · score 0.19
cystatin-SN measurement · score 0.17
cystatin-SA measurement · score 0.17
esophageal squamous cell carcinoma · score 0.08
dental caries · score 0.08
neoplasm · score 0.06
gonorrhea · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01036-F1	alphafold	PREDICTED	89.25	—

Amino-acid sequence (141 residues)

MARPLCTLLL LMATLAGALA SSSKEENRII PGGIYDADLN DEWVQRALHF AISEYNKATE DEYYRRPLQV LRAREQTFGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF EIYEVPWEDR MSLVNSRCQE A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards