Cystatin-SN (CST1)

About Cystatin-SN

Cystatin-SN (CST1) is a protein from Homo sapiens identified by UniProt accession P01037, 141 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Cystatin-SN
UniProt accession	P01037
Gene	CST1
Organism	Homo sapiens
Length	141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.43
cystatin-SN measurement · score 0.39
protein measurement · score 0.35
cystatin-SA measurement · score 0.30
cerebrospinal fluid biomarker measurement · score 0.29
esophageal squamous cell carcinoma · score 0.10
non-small cell lung carcinoma · score 0.09
lung adenocarcinoma · score 0.08
neoplasm · score 0.08
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01037-F1	alphafold	PREDICTED	92.54	—

Amino-acid sequence (141 residues)

MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF EIYEVPWENR RSLVKSRCQE S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards