Cystatin-A (CSTA)

About Cystatin-A

Cystatin-A (CSTA) is a protein from Homo sapiens identified by UniProt accession P01040, 98 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	Cystatin-A
UniProt accession	P01040
Gene	CSTA
Organism	Homo sapiens
Length	98 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (168)

Diseases linked to this target (Open Targets).

exfoliative ichthyosis · score 0.64
Hyperkeratosis · score 0.37
acral peeling skin syndrome · score 0.37
Hyperhidrosis · score 0.37
Palmoplantar hyperkeratosis · score 0.37
exfoliative dermatitis · score 0.37
Erythema · score 0.37
ichthyosis · score 0.37
calcium measurement · score 0.30
glioblastoma multiforme · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01040-F1	alphafold	PREDICTED	93.20	—

Amino-acid sequence (98 residues)

MIPGGLSEAK PATPEIQEIV DKVKPQLEEK TNETYGKLEA VQYKTQVVAG TNYYIKVRAG DNKYMHLKVF KSLPGQNEDL VLTGYQVDKN KDDELTGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards