About Kininogen-1
Kininogen-1 (KNG1) is a protein
from Homo sapiens identified by UniProt accession
P01042, 644 residues long.
MolForge cross-references it against 0 known binders and
610 disease associations.
Target properties
| Protein name | Kininogen-1 |
|---|
| UniProt accession | P01042 |
|---|
| Gene | KNG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 644 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (610)
Diseases linked to this target (Open Targets).
- congenital high-molecular-weight kininogen deficiency · score 0.72
- blood protein measurement · score 0.47
- kininogen-1 measurement · score 0.39
- partial thromboplastin time · score 0.39
- glomerular filtration rate · score 0.38
- creatinine measurement · score 0.38
- TNF-related apoptosis-inducing ligand measurement · score 0.36
- coagulation factor measurement · score 0.36
- factor XI measurement · score 0.36
- cystatin C measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01042-F1 | alphafold | PREDICTED | 65.89 | — |
Amino-acid sequence (644 residues)
MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS
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