Myc proto-oncogene protein (MYC)

About Myc proto-oncogene protein

Myc proto-oncogene protein (MYC) is a protein from Homo sapiens identified by UniProt accession P01106, 454 residues long. MolForge cross-references it against 0 known binders and 1,572 disease associations.

Target properties

Protein name	Myc proto-oncogene protein
UniProt accession	P01106
Gene	MYC
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1572)

Diseases linked to this target (Open Targets).

Burkitts lymphoma · score 0.64
neurodegenerative disease · score 0.54
urinary bladder carcinoma · score 0.50
prostate carcinoma · score 0.46
diffuse large B-cell lymphoma · score 0.44
lung adenocarcinoma · score 0.44
type 2 diabetes mellitus · score 0.43
asthma · score 0.43
neuroblastoma · score 0.43
lymphoma · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01106-F1	alphafold	PREDICTED	60.41	—

Amino-acid sequence (454 residues)

MDFFRVVENQ QPPATMPLNV SFTNRNYDLD YDSVQPYFYC DEEENFYQQQ QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVTPFSLRGD NDGGGGSFST ADQLEMVTEL LGGDMVNQSF ICDPDDETFI KNIIIQDCMW SGFSAAAKLV SEKLASYQAA RKDSGSPNPA RGHSVCSTSS LYLQDLSAAA SECIDPSVVF PYPLNDSSSP KSCASQDSSA FSPSSDSLLS STESSPQGSP EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQAPGK RSESGSPSAG GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRV KLDSVRVLRQ ISNNRKCTSP RSSDTEENVK RRTHNVLERQ RRNELKRSFF ALRDQIPELE NNEKAPKVVI LKKATAYILS VQAEEQKLIS EEDLLRKRRE QLKHKLEQLR NSCA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards