About GTPase NRas
GTPase NRas (NRAS) is a protein
from Homo sapiens identified by UniProt accession
P01111, 189 residues long.
MolForge cross-references it against 0 known binders and
800 disease associations.
Target properties
| Protein name | GTPase NRas |
|---|
| UniProt accession | P01111 |
|---|
| Gene | NRAS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 189 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (800)
Diseases linked to this target (Open Targets).
- Noonan syndrome 6 · score 0.80
- Noonan syndrome · score 0.79
- large congenital melanocytic nevus · score 0.76
- melanoma · score 0.75
- acute myeloid leukemia · score 0.74
- nevus, epidermal · score 0.74
- Juvenile Myelomonocytic Leukemia · score 0.73
- autoimmune lymphoproliferative syndrome type 4 · score 0.70
- RAS-associated autoimmune leukoproliferative disease · score 0.69
- multiple myeloma · score 0.68
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01111-F1 | alphafold | PREDICTED | 92.04 | — |
Amino-acid sequence (189 residues)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
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