About GTPase HRas
GTPase HRas (HRAS) is a protein
from Homo sapiens identified by UniProt accession
P01112, 189 residues long.
MolForge cross-references it against 0 known binders and
747 disease associations.
Target properties
| Protein name | GTPase HRas |
|---|
| UniProt accession | P01112 |
|---|
| Gene | HRAS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 189 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (747)
Diseases linked to this target (Open Targets).
- Costello syndrome · score 0.89
- linear nevus sebaceous syndrome · score 0.73
- Linear nevus sebaceus syndrome · score 0.71
- nevus, epidermal · score 0.70
- Noonan syndrome · score 0.68
- follicular thyroid carcinoma · score 0.68
- urinary bladder cancer · score 0.66
- urinary bladder carcinoma · score 0.66
- cancer · score 0.65
- head and neck squamous cell carcinoma · score 0.61
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01112-F1 | alphafold | PREDICTED | 91.95 | — |
Amino-acid sequence (189 residues)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMSCKCVLS
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