About GTPase KRas
GTPase KRas (KRAS) is a protein
from Homo sapiens identified by UniProt accession
P01116, 189 residues long.
MolForge cross-references it against 0 known binders and
1,007 disease associations.
Target properties
| Protein name | GTPase KRas |
|---|
| UniProt accession | P01116 |
|---|
| Gene | KRAS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 189 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1007)
Diseases linked to this target (Open Targets).
- cardiofaciocutaneous syndrome · score 0.83
- Noonan syndrome · score 0.83
- non-small cell lung carcinoma · score 0.77
- gastric cancer · score 0.77
- Juvenile Myelomonocytic Leukemia · score 0.76
- acute myeloid leukemia · score 0.75
- linear nevus sebaceous syndrome · score 0.73
- lung adenocarcinoma · score 0.72
- Linear nevus sebaceus syndrome · score 0.72
- Toriello-Lacassie-Droste syndrome · score 0.71
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01116-F1 | alphafold | PREDICTED | 91.52 | — |
Amino-acid sequence (189 residues)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCIIM
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