Platelet-derived growth factor subunit B (PDGFB)

About Platelet-derived growth factor subunit B

Platelet-derived growth factor subunit B (PDGFB) is a protein from Homo sapiens identified by UniProt accession P01127, 241 residues long. MolForge cross-references it against 0 known binders and 518 disease associations.

Target properties

Protein name	Platelet-derived growth factor subunit B
UniProt accession	P01127
Gene	PDGFB
Organism	Homo sapiens
Length	241 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (518)

Diseases linked to this target (Open Targets).

bilateral striopallidodentate calcinosis · score 0.75
Basal ganglia calcification · score 0.70
dermatofibrosarcoma protuberans · score 0.49
meningioma · score 0.45
familial meningioma · score 0.40
cancer · score 0.38
leiomyosarcoma · score 0.37
malignant peripheral nerve sheath tumor · score 0.37
undifferentiated pleomorphic sarcoma · score 0.37
congenital fibrosarcoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01127-F1	alphafold	PREDICTED	73.15	—

Amino-acid sequence (241 residues)

MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards