Protransforming growth factor alpha (TGFA)

About Protransforming growth factor alpha

Protransforming growth factor alpha (TGFA) is a protein from Homo sapiens identified by UniProt accession P01135, 160 residues long. MolForge cross-references it against 0 known binders and 743 disease associations.

Target properties

Protein name	Protransforming growth factor alpha
UniProt accession	P01135
Gene	TGFA
Organism	Homo sapiens
Length	160 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (743)

Diseases linked to this target (Open Targets).

cancer · score 0.48
osteoarthritis · score 0.46
grip strength measurement · score 0.45
osteoarthritis, knee · score 0.42
osteoarthritis, hip · score 0.40
heel bone mineral density · score 0.37
tooth agenesis · score 0.37
serum gamma-glutamyl transferase measurement · score 0.30
cartilage thickness measurement · score 0.29
injury · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01135-F1	alphafold	PREDICTED	66.45	—

Amino-acid sequence (160 residues)

MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards