Transforming growth factor beta-1 proprotein (TGFB1)

About Transforming growth factor beta-1 proprotein

Transforming growth factor beta-1 proprotein (TGFB1) is a protein from Homo sapiens identified by UniProt accession P01137, 390 residues long. MolForge cross-references it against 0 known binders and 2,766 disease associations.

Target properties

Protein name	Transforming growth factor beta-1 proprotein
UniProt accession	P01137
Gene	TGFB1
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (2766)

Diseases linked to this target (Open Targets).

Camurati-Engelmann disease · score 0.80
inflammatory bowel disease, immunodeficiency, and encephalopathy · score 0.69
myelodysplastic syndrome · score 0.57
cancer · score 0.53
anemia (phenotype) · score 0.48
Beta-thalassemia · score 0.47
Encephalopathy · score 0.46
immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome · score 0.45
cystic fibrosis · score 0.44
genetic disorder · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01137-F1	alphafold	PREDICTED	79.59	—

Amino-acid sequence (390 residues)

MPPSGLRLLP LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE ADYYAKEVTR VLMVETHNEI YDKFKQSTHS IYMFFNTSEL REAVPEPVLL SRAELRLLRL KLKVEQHVEL YQKYSNNSWR YLSNRLLAPS DSPEWLSFDV TGVVRQWLSR GGEIEGFRLS AHCSCDSRDN TLQVDINGFT TGRRGDLATI HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SAAPCCVPQA LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards