About Beta-nerve growth factor
Beta-nerve growth factor (NGF) is a protein
from Homo sapiens identified by UniProt accession
P01138, 241 residues long.
MolForge cross-references it against 0 known binders and
1,104 disease associations.
Target properties
| Protein name | Beta-nerve growth factor |
|---|
| UniProt accession | P01138 |
|---|
| Gene | NGF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 241 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1104)
Diseases linked to this target (Open Targets).
- hereditary sensory and autonomic neuropathy type 5 · score 0.75
- diastolic blood pressure · score 0.45
- erythrocyte count · score 0.43
- osteoarthritis · score 0.42
- systolic blood pressure · score 0.42
- hypertension · score 0.40
- osteoarthritis, knee · score 0.40
- osteoarthritis, hip · score 0.39
- cardiovascular disease · score 0.39
- Diuretic use measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01138-F1 | alphafold | PREDICTED | 73.23 | — |
Amino-acid sequence (241 residues)
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
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