Progonadoliberin-1 (GNRH1)

About Progonadoliberin-1

Progonadoliberin-1 (GNRH1) is a protein from Homo sapiens identified by UniProt accession P01148, 92 residues long. MolForge cross-references it against 0 known binders and 922 disease associations.

Target properties

Protein name	Progonadoliberin-1
UniProt accession	P01148
Gene	GNRH1
Organism	Homo sapiens
Length	92 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (922)

Diseases linked to this target (Open Targets).

isolated congenital hypogonadotropic hypogonadism · score 0.54
isolated thyroid-stimulating hormone deficiency · score 0.41
hypogonadotropic hypogonadism · score 0.39
age at menopause · score 0.35
lean body mass · score 0.32
heel bone mineral density · score 0.30
mean platelet volume · score 0.29
uterine fibroid · score 0.26
menstrual cycle measurement · score 0.25
age at menarche · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01148-F1	alphafold	PREDICTED	72.16	—

Amino-acid sequence (92 residues)

MKPIQKLLAG LILLTWCVEG CSSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR FECTTHQPRS PLRDLKGALE SLIEEETGQK KI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards