Natriuretic peptides A (NPPA)

About Natriuretic peptides A

Natriuretic peptides A (NPPA) is a protein from Homo sapiens identified by UniProt accession P01160, 151 residues long. MolForge cross-references it against 0 known binders and 981 disease associations.

Target properties

Protein name	Natriuretic peptides A
UniProt accession	P01160
Gene	NPPA
Organism	Homo sapiens
Length	151 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (981)

Diseases linked to this target (Open Targets).

familial atrial fibrillation · score 0.51
Atrial stand still · score 0.49
AL amyloidosis · score 0.46
atrial standstill · score 0.38
diastolic blood pressure · score 0.33
systolic blood pressure · score 0.29
breast adenocarcinoma · score 0.23
smoking status measurement · score 0.21
pulse pressure measurement · score 0.20
blood protein measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01160-F1	alphafold	PREDICTED	63.48	—

Amino-acid sequence (151 residues)

MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards