Oxytocin-neurophysin 1 (OXT)

About Oxytocin-neurophysin 1

Oxytocin-neurophysin 1 (OXT) is a protein from Homo sapiens identified by UniProt accession P01178, 125 residues long. MolForge cross-references it against 0 known binders and 603 disease associations.

Target properties

Protein name	Oxytocin-neurophysin 1
UniProt accession	P01178
Gene	OXT
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (603)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.22
neurodegenerative disease · score 0.21
medulloblastoma · score 0.13
Neurodevelopmental disorder · score 0.12
post-traumatic stress disorder · score 0.11
schizophrenia · score 0.11
anxiety · score 0.11
Borderline personality disorder · score 0.10
acanthosis nigricans · score 0.10
social anxiety disorder · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01178-F1	alphafold	PREDICTED	83.81	—

Amino-acid sequence (125 residues)

MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA TFSQR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards