About Pro-opiomelanocortin
Pro-opiomelanocortin (POMC) is a protein
from Homo sapiens identified by UniProt accession
P01189, 267 residues long.
MolForge cross-references it against 0 known binders and
1,540 disease associations.
Target properties
| Protein name | Pro-opiomelanocortin |
|---|
| UniProt accession | P01189 |
|---|
| Gene | POMC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 267 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1540)
Diseases linked to this target (Open Targets).
- obesity due to pro-opiomelanocortin deficiency · score 0.69
- obesity · score 0.61
- inherited obesity · score 0.48
- genetic disorder · score 0.41
- adrenal gland disease · score 0.37
- body weight · score 0.35
- body mass index · score 0.35
- lean body mass · score 0.32
- IGF-1 measurement · score 0.32
- body fat percentage · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01189-F1 | alphafold | PREDICTED | 57.66 | — |
Amino-acid sequence (267 residues)
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC KPDLSAETPM FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA GQKREDVSAG EDCGPLPEGG PEPRSDGAKP GPREGKRSYS MEHFRWGKPV GKKRRPVKVY PNGAEDESAE AFPLEFKREL TGQRLREGDG PDGPADDGAG AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF MTSEKSQTPL VTLFKNAIIK NAYKKGE
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