About Proenkephalin-A
Proenkephalin-A (PENK) is a protein
from Homo sapiens identified by UniProt accession
P01210, 267 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Proenkephalin-A |
|---|
| UniProt accession | P01210 |
|---|
| Gene | PENK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 267 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (237)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.39
- blood protein measurement · score 0.38
- type 2 diabetes mellitus · score 0.33
- body height · score 0.31
- diet measurement · score 0.28
- glioblastoma multiforme · score 0.26
- alcohol use disorder measurement · score 0.26
- ovarian cancer · score 0.25
- protein measurement · score 0.24
- head and neck squamous cell carcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01210-F1 | alphafold | PREDICTED | 60.48 | — |
Amino-acid sequence (267 residues)
MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM ECEGKLPSLK IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY GGFMKRYGGF MKKMDELYPM EPEEEANGSE ILAKRYGGFM KKDAEEDDSL ANSSDLLKEL LETGDNRERS HHQDGSDNEE EVSKRYGGFM RGLKRSPQLE DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA LPSDEEGESY SKEVPEMEKR YGGFMRF
Explore Proenkephalin-A with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets