Glycoprotein hormones alpha chain (CGA)

About Glycoprotein hormones alpha chain

Glycoprotein hormones alpha chain (CGA) is a protein from Homo sapiens identified by UniProt accession P01215, 116 residues long. MolForge cross-references it against 0 known binders and 215 disease associations.

Target properties

Protein name	Glycoprotein hormones alpha chain
UniProt accession	P01215
Gene	CGA
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (215)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
eosinophil count · score 0.34
Alzheimer disease · score 0.33
Parkinson disease · score 0.33
multiple sclerosis · score 0.33
lysosomal storage disease · score 0.33
sitting height measurement · score 0.29
lung adenocarcinoma · score 0.27
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01215-F1	alphafold	PREDICTED	91.83	—

Amino-acid sequence (116 residues)

MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV ENHTACHCST CYYHKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards