Thyrotropin subunit beta (TSHB)

About Thyrotropin subunit beta

Thyrotropin subunit beta (TSHB) is a protein from Homo sapiens identified by UniProt accession P01222, 138 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Thyrotropin subunit beta
UniProt accession	P01222
Gene	TSHB
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

isolated thyroid-stimulating hormone deficiency · score 0.74
congenital hypothyroidism · score 0.37
cutaneous melanoma · score 0.24
endometrial cancer · score 0.18
genetic disorder · score 0.18
vital capacity · score 0.14
body mass index · score 0.13
neutrophil count · score 0.11
gastric adenocarcinoma · score 0.11
breast adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01222-F1	alphafold	PREDICTED	86.02	—

Amino-acid sequence (138 residues)

MTALFLMSML FGLTCGQAMS FCIPTEYTMH IERRECAYCL TINTTICAGY CMTRDINGKL FLPKYALSQD VCTYRDFIYR TVEIPGCPLH VAPYFSYPVA LSCKCGKCNT DYSDCIHEAI KTNYCTKPQK SYLVGFSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards